Showed no toxicity on normal lung cells, and mentioned that: Non-small-cell lung cancer (NSCLC) A549-induced BALB/c mice were fed with 150 and 300 mg/kg M. citrifolia and compared with Erlotinib (50mg/kg body weight) for 21 days. It significantly increased the pro-apoptic TRP53 genes, down regulated the pro-tumourignensis genes in the mice tumours, significantly increased the anti-inflammatory IL4, IL10 and NR3C1 expression in the metastasized lung and hepatic cancer tissues and enhanced the NFE2L2-dependent antioxidant responses against oxidative injuries. The extract elevated serum neutrophils and reduced the red blood cells, haemoglobin, corpuscular volume and cell haemoglobin concentration in the lung cancer-induced mammal. It suppressed inflammation and oedema, and upregulated the endogenous antioxidant responses and apoptotic genes to suppress the cancer. The 300 mg/kg extract was more effective than the 50 mg/kg Erlotinib for most of the parameters measured.
"We have a multi-billion dollar industry that is killing people, right and left, just for financial gain. Their idea of research is to see whether two doses of this poison are better than three doses of that poison."– Glen Warner, M.D. oncologist (source)
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The implications of this research are truly profound. Erlotinib (trade name Tarceva) can cost upwards of $7,700 a month (150 mg a day), depending on the drug dose used. Ironically, since the drug doesn't actually prolong survival effectively, the profit gravy train runs dry sooner than later because the patient dies. If indeed the drug prolonged survival a year, would it be worth the 30,000 to 90,000 it costs? Perhaps, if you could afford it. When you compare the price of Noni leaf extract, which can cost as low as 12 cents per 250 mg extract, you begin to see just how skewed our concept of value is. How could a chemotherapy agent, with deadly side effects, that can easily bankrupt a family if they are forced to pay out of pocket, be offered as the only choice to those with cancer when something that is practically free, safe, and has been proven effective in this way? (source)